David M Holtzman Selected Research

Alzheimer Disease (Alzheimer's Disease)

2/2022	APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease.
1/2022	Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau.
1/2022	APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model.
1/2022	ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias.
1/2022	Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment.
1/2022	Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
1/2022	Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis.
1/2022	Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains.
12/2021	STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks.
11/2021	Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET.

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David M Holtzman Research Topics

Disease

269	Alzheimer Disease (Alzheimer's Disease) 02/2022 - 03/2002
61	Amyloid Plaque 01/2022 - 03/2002
38	Cognitive Dysfunction 01/2022 - 03/2002
32	Dementia (Dementias) 01/2022 - 07/2003
22	Amyloidosis 01/2022 - 08/2004
20	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2002
18	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2021 - 08/2003
17	Tauopathies 01/2022 - 10/2014
14	Atrophy 01/2022 - 12/2011
13	Neuroinflammatory Diseases 02/2022 - 08/2009
12	Brain Injuries (Brain Injury) 01/2017 - 01/2002
10	Disease Progression 01/2020 - 12/2006
9	Inflammation (Inflammations) 02/2022 - 06/2007
9	Ischemia 01/2021 - 01/2002
7	Sleep Deprivation 01/2020 - 11/2009
7	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2012 - 12/2002
5	Memory Disorders (Memory Loss) 11/2017 - 01/2004
5	Hypoxia (Hypoxemia) 10/2017 - 01/2002
5	Seizures (Absence Seizure) 07/2013 - 10/2006
3	Gliosis 01/2021 - 12/2013
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 02/2013
3	Obstructive Sleep Apnea 01/2019 - 01/2016
3	Sleep Wake Disorders 08/2017 - 01/2014
3	Hydrocephalus (Hydrocephaly) 01/2017 - 01/2015
3	Infarction (Infarctions) 10/2014 - 07/2002
3	Nervous System Diseases (Neurological Disorders) 01/2012 - 09/2006
3	Stroke (Strokes) 01/2007 - 07/2002
3	Hemorrhage 03/2005 - 08/2003
2	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2020
2	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 06/2012
2	Down Syndrome (Down's Syndrome) 01/2021 - 05/2012
2	Demyelinating Diseases (Demyelinating Disease) 10/2020 - 06/2014
2	Neurobehavioral Manifestations 01/2018 - 04/2014
2	Cerebral Cortical Thinning 01/2018 - 11/2013
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 10/2017 - 01/2017
2	Multiple Sclerosis 01/2017 - 06/2014
2	Proteostasis Deficiencies 01/2017 - 11/2012
2	Central Nervous System Diseases (CNS Diseases) 01/2016 - 12/2005
2	Neuroblastoma 03/2015 - 12/2009
2	Ischemic Stroke 02/2015 - 04/2006
2	Epilepsy (Aura) 07/2013 - 03/2010
2	Tuberous Sclerosis (Bourneville's Disease) 03/2010 - 11/2007
2	Mitochondrial Diseases (Mitochondrial Disease) 04/2009 - 06/2006
1	Lewy Body Disease (Lewy Body Dementia) 01/2022
1	Infections 01/2022

Drug/Important Bio-Agent (IBA)

155	Amyloid (Amyloid Fibrils)IBA 02/2022 - 03/2002
88	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2003
68	Apolipoproteins E (ApoE)IBA 02/2022 - 04/2002
59	Amyloid beta-PeptidesIBA 11/2016 - 03/2002
49	ApolipoproteinsIBA 01/2022 - 04/2002
45	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2002
44	Peptides (Polypeptides)IBA 01/2022 - 03/2002
19	Apolipoprotein E4IBA 02/2022 - 12/2002
18	Protein Isoforms (Isoforms)IBA 01/2022 - 04/2002
12	tau Proteins (tau Protein)IBA 10/2021 - 06/2011
9	EnzymesIBA 11/2017 - 09/2003
8	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2019 - 12/2009
6	LipidsIBA 01/2021 - 03/2012
6	AntibodiesIBA 10/2019 - 12/2002
5	Biological ProductsIBA 01/2019 - 01/2010
5	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 04/2012 - 02/2011
5	Caspase 3 (Caspase-3)IBA 04/2009 - 01/2002
4	LDL Receptors (LDL Receptor)IBA 01/2021 - 01/2004
4	NeurograninIBA 01/2021 - 11/2015
4	CholesterolIBA 01/2021 - 10/2004
4	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2019 - 06/2012
4	Amino Acids FDA Link 01/2018 - 01/2006
4	OrexinsIBA 08/2017 - 11/2009
4	Presenilin-1IBA 01/2012 - 10/2006
3	Apolipoprotein E3IBA 01/2022 - 03/2005
3	Antisense OligonucleotidesIBA 01/2021 - 07/2013
3	Pharmaceutical PreparationsIBA 01/2021 - 07/2009
3	NeurocalcinIBA 01/2019 - 08/2011
3	Protein AggregatesIBA 10/2018 - 08/2009
3	IsotopesIBA 08/2017 - 01/2006
3	LigandsIBA 01/2016 - 10/2005
3	thioflavin TIBA 10/2014 - 02/2008
3	Threonine (L-Threonine)FDA Link 12/2013 - 05/2009
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2021
2	Therapeutic UsesIBA 01/2022 - 01/2021
2	SaltsIBA 01/2020 - 10/2019
2	Chitinase-3-Like Protein 1IBA 01/2019 - 09/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 11/2013
2	Nicotinamide MononucleotideIBA 10/2017 - 11/2011
2	Insulin (Novolin)FDA Link 11/2016 - 01/2016
2	Lactic Acid (Lactate)FDA LinkGeneric 02/2016 - 06/2015
2	Indicators and Reagents (Reagents)IBA 01/2016 - 11/2010
2	Apolipoprotein E2IBA 01/2016 - 01/2012
2	Adenosine Triphosphate (ATP)IBA 06/2015 - 04/2012
2	VaccinesIBA 06/2012 - 07/2008
2	CaspasesIBA 11/2011 - 08/2002
2	ImmunosorbentsIBA 09/2011 - 11/2010
2	Sulfoglycosphingolipids (Sulfatides)IBA 07/2010 - 07/2003
2	Glutamic Acid (Glutamate)FDA Link 03/2010 - 11/2007
2	CarbonatesIBA 11/2006 - 12/2005
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2005 - 09/2003

Therapy/Procedure

23	Therapeutics 01/2020 - 12/2002
4	Immunotherapy 01/2021 - 01/2005
2	Secondary Prevention 01/2018 - 09/2015
2	Ligation 06/2005 - 01/2002